Unlike full-length mAbs, however, fragments (unless designed otherwise) fail to induce effector functions that require an Fc domain, such as antibody ... six bispecific Fab candidate fragments ...

Antibodies induce antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity and efficient cross-presentation by APCs through the Fc portion. Novel technologies aiming at ...

Examples of antibody sequences accepted: variable region sequenced from hybridoma, hits (Fab or scFv) selected from display library based method, sequences from single B cell and/or repertoire ...