Antibodies and related products are the fastest growing class of therapeutic agents. By analysing the regulatory approvals of IgG-based biotherapeutic agents in the past 10 years, we can gain ...

Changes in glycosylation are often associated with ... intracellular sialic acid levels is untenable by current lectin or antibody methods. In a cellular model system these mutations can be ...

Bleiholder's team confirmed that structural variations among antibody populations are not influenced by glycosylation—a process in which sugar molecules attach to other molecules. The research ...

IgG inhibition of a monoclonal antibody therapy can help with the selected deactivation of serum IgG with EndoS. Peptide glycosylation can be achieved using a two-step process involving EndoA or ...

From left, Florida State University faculty researcher Fanny C. Liu and Christian Bleiholder, a professor in the Department of Chemistry and ...

New research from the Florida State University Department of Chemistry and Biochemistry shows that a particular type of monoclonal antibody known as NISTmAb retains its structure even if the sugar ...

The anti-TA-MUC1 is the antibody contained in DS-3939 ... MUC1 is a tumor-specific transmembrane glycoprotein with aberrant glycosylation due to changes of the expression patterns of some ...

Most individuals infected with HIV-1 develop neutralizing antibodies (Nab) capable of eliminating autologous viruses in vitro ... and primarily involved changes in N-linked glycosylation. In addition, ...

The anti-TA-MUC1 is the antibody contained in DS-3939, an ADC being developed by Daiichi Sankyo ... TA-MUC1 is a tumour-specific transmembrane glycoprotein with aberrant glycosylation due to changes ...