Several types of human cancer, particularly colon cancer ... the authors identified a number of residues in the Frizzled 8 CRD that, when mutated, disrupt Wnt binding (shown in red for one ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...