An unexpected mechanism regulates the immune response during parasitic infections
Researchers at the University of Liège (Belgium) have uncovered a previously unknown mechanism that regulates the immune ...
technologynetworks4d
Mechanism That Regulates Immune Responses to Parasites Identified for the First Time
Researchers at the University of Liège (Belgium) have uncovered a previously unknown mechanism that regulates the immune ...
AZoLifeSciences on MSN3d
Uncovering a New Mechanism in Immune Cell Regulation During Parasitic Infections
Researchers at the University of Liège (Belgium) have uncovered a previously unknown mechanism that regulates the immune ...
MedCity News15d
Safety Risk Sinks Cargo Therapeutics’ Cancer Cell Therapy Prospect, Leading to 50% Staff Cut
Firi-cel is an autologous cell therapy designed to target the cancer protein CD22, providing an alternative to currently available cell therapies that target CD19. Cancers escape CD19-targeting ...
BioPharma Dive14d
Cargo to drop lead CAR-T therapy, lay off staff after study setback
Safety concerns and disappointing results led Cargo to stop testing the treatment, cut 50% of its workforce and evaluate strategic alternatives.
Nature10d
Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro
Mabs directed against the cell surface antigens, CD19 and CD22 conjugated to deglycosylated ricin A chain (dgRTA) have been tested in patients with non-Hodgkin's lymphoma (NHL), but not in ...
BioWorld14d
Cargo stops firi-cel phase II on safety, durability; stock sinks
In a devastating blow to the company and large B-cell lymphoma patients relapsed or refractory to CD19 CAR T-cell therapy, Cargo Therapeutics Inc. terminated the phase II study of its lead CD22 cell ...
生物通4d
Science子刊：一种意想不到的机制调节了寄生虫感染期间的免疫反应
比利时里昂热大学的研究人员发现了一种以前未知的调节针对寄生虫的免疫反应的机制。在寄生虫感染期间，被称为虚拟记忆T细胞（TVM）的特异性免疫细胞被激活并表达一种称为CD22的表面分子，这种分子可以防止过度的免疫反应。这一发现可能有助于更好地控制炎症和提高对感染的免疫反应。