DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce ...

Guarding genes against damage is a crucial and complex job, so it’s to be expected that cells have several mechanisms to repair DNA breakages, each providing support under different circumstances.

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

PARylation is integral to many key cellular functions, including signaling modulation and DNA repair. PARylation is reversible and is undone by PAR erasers such as poly ADP-ribose glycohydrolase (PARG ...

"This basically increases energy in the body and helps repair DNA," Love shares. As NAD+ levels naturally decline with age, NR supplementation helps replenish this critical molecule, supporting ...

For this reason, they are at greater risk of accumulating damage and must develop alternative repair pathways to avoid dysfunction. Scientists do not understand how neuronal DNA damage is ...