Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...

UC San Diego researchers have identified the molecular and cellular mechanisms that transform healthy stem cells into oral cancer at the earliest stages of the disease ...

Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an oestrogen independent manner. Targeting vimentin and/or the long ...

Impact of the stem cell niche on aging: we study the communication between stem cells and their niche (e.g. neighbor cells, ECM) in multiple tissues including the intestine, mammary, skeletal muscle, ...

Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including milk thistle, turmeric, and green tea, that target the tumor ...

The Under-oil Open Microfluidic System enhances tumor cell-ECM interaction studies, improving anti-metastatic drug testing for triple-negative breast cancer.

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its ...

Organization of different cell types and the extracellular ... tissue regeneration or to hypertrophy and cancer. We investigate how the composition and dynamics of basement membrane, a specialised ...

However, glial cells in the brain continue to divide throughout a mammal's adult life. Mammalian epithelial cells also turn over regularly, typically every few days. Whenever stem cells are called ...

Tendon stem cells differentiate into tenocytes (Zhang, 2010); the predominant cell type within tendon, responsible for producing extracellular matrix (ECM). The local stem cell environment (niche) is ...

Researchers have identified the molecular and cellular mechanisms that transform healthy stem cells into oral cancer at the earliest stages of the disease. Nearly 60,000 people are diagnosed with oral ...