Impact of the stem cell niche on aging: we study the communication between stem cells and their niche (e.g. neighbor cells, ECM) in multiple tissues including the intestine, mammary, skeletal muscle, ...

Organization of different cell types and the extracellular matrix (ECM ... interplay can lead to complications in tissue regeneration or to hypertrophy and cancer. We investigate how the composition ...

A recent article in Small highlights a new method for studying tumor cell interactions and testing anti-metastatic drugs through the development of an Under-oil Open Microfluidic System (UOMS).

Tendon stem cells differentiate into tenocytes (Zhang, 2010); the predominant cell type within tendon, responsible for producing extracellular matrix (ECM). The local stem cell environment (niche) is ...

Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including milk thistle, turmeric, and green tea, that target the tumor ...

D tumoroid models transform cancer research, accurately reflecting tumor biology and enabling effective drug testing and ...

An international research team led by a Boston College professor has uncovered a drug and diet pairing that could fight a deadly brain cancer The international team combined a calorie-restricted diet ...

The numerous cells that make up mammalian tissues are surrounded by an intricate network of proteins known as the extracellular matrix (ECM). Together, these proteins provide cells with a structural ...

Organoids contain multiple organ-specific cell types ... other and ECM proteins, thereby mimicking the functionality and structure of organs in vivo. This allows researchers to model organ-specific ...