The Framingham Heart Study, which first applied the principles of epidemiology to cardiovascular disease and laid the foundations for the development of antihypertensives and lipid-lowering drugs ...

Tool and Study Selection: We included risk calculation tools that used the Framingham risk equations to generate a global coronary heart disease ... including risk charts and computerized ...

was selected as the study site. More than 5,200 healthy men and women volunteered to participate in what soon became known as the Framingham Heart Study. Researchers gathered a detailed medical ...