An antibody molecule consists of two heavy chains (approximately 50 kDa each) and two light chains (approximately 25 kDa each). These chains are interconnected by disulfide bonds, resulting in a ...

A full-size IgG antibody is a Y-shaped complex of two identical light chains, each with a variable and constant domain, and two heavy chains, each with one variable and three constant domains.

The method for creating bispecific κλ bodies is simple: a production cell expresses a single heavy chain, alongside κ and λ light chains, which self-assemble into functional antibodies.

Recombinant antibodies are invented antibodies formed by using recombinant DNA technology. While traditional monoclonal ...

Lonza’s bYlok® technology is changing the way bispecific antibodies are designed. Achieving the correct heterodimerization of light and heavy chains during bispecific production can be challenging, ...