An antibody molecule consists of two heavy chains (approximately 50 kDa each) and two light chains (approximately 25 kDa each). These chains are interconnected by disulfide bonds, resulting in a ...

A full-size IgG antibody is a Y-shaped complex of two identical light chains, each with a variable and constant domain, and two heavy chains, each with one variable and three constant domains.

The method for creating bispecific κλ bodies is simple: a production cell expresses a single heavy chain, alongside κ and λ light chains, which self-assemble into functional antibodies.

Recombinant antibodies are invented antibodies formed by using recombinant DNA technology. While traditional monoclonal ...

Lonza’s bYlok® technology is changing the way bispecific antibodies are designed. Achieving the correct heterodimerization of light and heavy chains during bispecific production can be challenging, ...

The heavy and light chains of that fully human anti-human eosinophil mAb were delivered via an adeno-associated virus (AAV)-based gene therapy to immunodeficient mice, where they suppressed levels ...