During development, there are known sex-related differences in how microglia function. But into adulthood, there was thought to be less variation in how they behave. Microglia maintain neuronal ...

A study led by Turkish researcher Pinar Ayata unveiled a critical mechanism involving microglia—specialized immune cells in the brain—that could open new avenues for treating Alzheimer's ...

Researchers at University of Tsukuba have discovered a novel mechanism involved in brain development. They found that small fragments called micronuclei produced by neuronal nuclei are released into ...

Scientists provide new evidence that preventing brain inflammation is a promising approach for the treatment of Alzheimer's disease. Their findings, based on studies in cell culture, mice and tissue ...

At the same time microglia can’t respond normally to this early nondegenerative process, which accelerates it.” All of this remains to be tested, he added. For her part, Young will use hiPSC ...

Their findings, based on studies in cell culture, mice and tissue samples from patients ... Specifically, we pharmacologically manipulated a molecular complex called the NLRP3 inflammasome. It is ...

Shane Liddelow, New York University After the researchers demonstrated that the astrocytes were growing without baseline reactivity in culture, they transitioned the astrocytes to a pathogenic state ...

Their findings, based on studies in cell culture, mice and tissue samples ... NLRP3 not only reduces neuroinflammation, but also helps microglia clear the harmful amyloid-beta deposits, a process ...

Scientists from DZNE , University Hospital Bonn (UKB) and the University of Bonn provide new evidence that preventing brain inflammation is a ...