They also remove plaques and prune dysfunctional synapses between neurons. Microglia eliminate their targets by eating them: they envelope material and seal it in bubble-like organelles called ...

View Full Profile. Learn about our Editorial Policies. Microglia, the brain’s primary immune cells that prune extra synapses during brain development, also regulate forgetting in the adult mouse brain ...

Microglia are immune cells in the central ... They remove damaged or unnecessary neurons, prune synapses during development ...

Microglia’s stress response drives toxic lipid production linked to Alzheimer’s progression. Blocking stress or lipid pathways reversed synapse loss in preclinical Alzheimer’s models. Findings ...

Recent studies have identified alterations in microglia leading to detrimental effects on the pruning process of both synapses, neural progenitor cells, and more recently, oligodendrocytes. Dr. Nemes ...