Medscape20d
Instigation of Notch Signaling in the Pathogenesis of Kaposi's Sarcoma-associated Herpesvirus and Other Human Tumor Viruses
These ligands in turn bind to Notch receptors (Notch1 and 4) in the adjacent cells, which results in sequential proteolytic cleavages by ADAM and γ-secretase, which release the NICD into the nucleus.