Cut off any part of this worm's body and it will regrow. This is the spectacular yet mysterious regenerative ability of ...

We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog ... agents that function by fine-tuning the Wnt pathway. This article describes major milestones that have ...

The authors therefore proposed that targeting this vital step in Notch pathway signalling may represent a new therapeutic approach. First, using phage display technology, the authors generated ...

"The Notch signaling pathway, and the immune cells involved, is not only well-conserved across species, but also across ...

The data also revealed an association between age-related bone degeneration and a significant upregulation of Notch signaling genes, suggesting that this pathway becomes abnormally active in SSPC as ...

Specifically, we would like to understand how these glycosyltransferases regulate the activity of the Notch signaling pathway in a dosage-sensitive and tissue-specific manner. We have reported a mouse ...