Scientists identify key protein in the inflammatory pathway driving fatty liver disease
"The Notch signaling pathway, and the immune cells involved, is not only well-conserved across species, but also across ...
The Scientist1y
A Molecular Switch for Bone Loss
The data also revealed an association between age-related bone degeneration and a significant upregulation of Notch signaling genes, suggesting that this pathway becomes abnormally active in SSPC as ...
Nature5y
A Notch closer
The authors therefore proposed that targeting this vital step in Notch pathway signalling may represent a new therapeutic approach. First, using phage display technology, the authors generated ...
Nature4y
Genetic Signaling: Transcription Factor Cascades and Segmentation
Spinal development, however, is controlled by an oscillating process that is dependent on a group of genes in the Notch pathway, only some of which have homologues in the Drosophila segmentation ...
Fred Hutch10y
Irwin Bernstein, MD
His team has also learned how a set of signals called the Notch pathway prompt blood stem cells to multiply. A Fred Hutch spinoff, Nohla Therapeutics, is now building on this discovery to develop ...
Baylor College of Medicine1y
Hamed Jafar-Nejad Lab
Specifically, we would like to understand how these glycosyltransferases regulate the activity of the Notch signaling pathway in a dosage-sensitive and tissue-specific manner. We have reported a mouse ...