Genetics researchers studied eFAD families to discover the three known genes that cause familial AD: amyloid precursor protein (APP), presenilin-1 (PS1), and presenilin-2 (PS2). Of these, PS1 ...

Disruption of calcium homeostasis, inhibition of protein glycosylation, and various cellular stresses provoke the accumulation of unfolded protein in the endoplasmic reticulum (ER); this ...

EBP1 is low in Alzheimer’s disease brains, hinting at human relevance. “Our study suggests that … preservation of functional EBP1 could be a therapeutic strategy for AD,” the authors noted. The ...

Tanzi, W. Wasco, L. Lannfelt, D. Selkoe, S. Younkin, "Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP ...