In untrained hands, propofol can be dangerous, even deadly; administration to a nonventilated patient by a practitioner who is not trained in the use of drugs that can cause deep sedation and ...

Propofol sedation by nonanesthesiologists is still a highly controversial issue despite the fact that numerous studies have approved this sedation regimen for gastrointestinal endoscopy.

The patients in the midazolam group performed markedly worse 2 h after sedation, compared with baseline, but the driving skills of the patients in the propofol group were almost unaffected.