The divergence of new genes and proteins occurs through mutations that modulate protein function. The effects of these mutations are pleiotropic, thus imposing trade-offs between selection ...

Researchers develop early Alzheimers diagnostic method using tau protein analysis Advancements in Alzheimers detection reveal ...

SEC-MX enables simultaneous quantitative differential analysis of protein assembly states and ... methods have been developed to understand how mutations drive tumourigenesis, but their insights ...

Improving our understanding of the impact of mutations on protein localization is essential ... powerful microscope—as well as computational analysis to fill in gaps in their visual analysis ...

This paper addresses the important question of quantifying epistasis patterns, which affect the predictability of evolution, by reanalyzing a recently published combinatorial deep mutational scan ...

DNA contains genes that carry instructions for the manufacture of a protein. If a mutation occurs in a gene that results in a change to the sequence of DNA bases, then the structure of the protein ...

Ignite Proteomics announces the publication of a significant study in the British Journal of Cancer titled “Functional activation of the ...

Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual ...

Ignite Proteomics offers the only commercially available and clinically validated assay that measures both the expression and activation levels of drug targets in breast tumors. This innovative ...

For years, scientists have focused on amyloid beta buildup as the main culprit in Alzheimer’s disease, but a new study suggests the real problem might lie in a stalled protein-cutting process in the ...

"Moreover, clinical trials of treatments targeting Aβ protein or its aggregates ... the team expanded their analysis to a further six mutations found in early onset FAD, measuring the impact ...