The Discovery of New Members of the TNF Receptor and Ligand Families and Their Relationship to Osteoclasts and Bone Metabolism Binding of RANKL to RANK initiates a signaling cascade, which ...

In contrast, TLRs 3, 7, 8, and 9 are situated in the membranes of endosomes and lysosomes; the extracellular domain of the receptor and its ligand-binding site project into the interior of these ...

More information: Jiuyin Xu et al, Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.

The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?

The ability to alter protein binding can create tailored therapeutics with reduced side effects, sensitive diagnostic tools, ...

Sigma-2 receptor modulation using exogenous ligands reduces cellular damage associated with central nervous system degeneration in age-related pathologies such as Alzheimer’s disease, Parkinson’s ...

Epidermal growth factor receptor (EGFR) is a major driver of cancer dissemination and target for anti-cancer therapies but ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments—water, lipid membranes, or other condensed phases—are critical to their ...

Ligand Pharmaceuticals Incorporated ... a dual endothelin and angiotensin II receptor antagonist in development for rare kidney diseases and non-immunosuppressive treatment indicated for ...

Hantz Financial Services Inc. acquired a new position in Ligand Pharmaceuticals Incorporated (NASDAQ:LGND – Free Report) during the fourth quarter, according to the company in its most recent filing ...

Researchers now offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ligand-binding proteins. In biology, the binding of cellular proteins ...