Interactions at a ligand binding level had been proposed and were strengthened by mounting pharmacological evidence. Binding assays were critical in assessing the hypothesis that opioid receptors ...

The Discovery of New Members of the TNF Receptor and Ligand Families and Their Relationship to Osteoclasts and Bone Metabolism Binding of RANKL to RANK initiates a signaling cascade, which ...

We provide comprehensive molecular modeling solutions tailored specifically for ligand design with cutting-edge tools at our disposal. With specialized expertise in GPCRs (G protein-coupled receptors) ...

Sigma-2 receptor modulation using exogenous ligands reduces cellular damage associated with central nervous system degeneration in age-related pathologies such as Alzheimer’s disease, Parkinson’s ...

Epidermal growth factor receptor (EGFR) is a major driver of cancer dissemination and target for anti-cancer therapies but ...

More information: Jiuyin Xu et al, Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.

Researchers now offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ligand-binding proteins. In biology, the binding of cellular proteins ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments—water, lipid membranes, or other condensed phases—are critical to their ...