A wide range of defects in renal tubular function, with normal glomerular filtration rate, were detected in these patients. The defects included decreases in the threshold and maximal reabsorptive ...

These include renal wasting of sodium and potassium, a renal concentrating defect and renal tubular acidosis. In other forms of renal tubular acidosis, renal potassium wastage also occurs and is ...

The authors postulated that the defect was either a deficiency of liver xanthine oxidase or a renal tubular defect with greatly increased renal tubular clearance of xanthine. In 1959 the same ...