WSU researchers have created HuT mice with human-like short telomeres, allowing for groundbreaking studies on aging, cancer, ...

Globally, scientists are working to unlock the secrets of extending human lifespan at the cellular level, where aging occurs gradually due to the shortening of telomeres–the protective caps at the ...

Every time a cell in the body replicates, the telomere gets shorter. When it gets too short, the cell dies. Just how telomere length may be asociated with heart disesae can be explained by the ...

When telomeres reduce to critically short lengths, they become unable to bind adequate telomere-capping proteins. 7 This condition of exposed DNA ends triggers the DNA damage response pathway, which ...

The evidence supporting the relevance of replicative senescence of human cells and telomere biology to human cancer is now quite strong. The evidence linking replicative senescence to human aging ...

People with shorter telomeres, the protective caps at the end of chromosomes, inside their white blood cells may be more ...

The mouse model in the study is reportedly quite different as it allows scientists to observe the aging process in a whole ...

Furthermore, these cells undergo apoptosis when their telomeres reach a critically short length, and such cells are no longer tumorigenic in immunodeficient mice. These results indicate that ...

New data suggest venetoclax may offset the negative prognostic impact of short telomeres in patients with chronic lymphocytic leukemia (CLL). A pair of studies examining the role of venetoclax ...

Research from Umeå University paves the way for a quantitative data analysis method to study the cell division process in ...

Cells undergo replicative senescence when telomeres shorten to a critical length, arresting the cell cycle. Critically short telomeres increase mortality risk. For instance, in human leukocytes ...

Elixirgen Therapeutics, Inc. is a clinical-stage biotechnology company focused on the treatment of rare diseases and aging-associated diseases using its ZSCAN4 technology and mRNA platform ...