Figure 2: Effects of WT-hTERT and DN-hTERT on telomerase activity. Figure 3: Effects of DN-hTERT expression on telomere length. Several lines of evidence now indicate that activation of telomerase ...

Scientists have used cell and animal models to provide proof of concept for the potential efficacy of telomerase activation-based therapeutic strategies that counteract changes in telomere shortening ...

Mutations that compromise telomerase’s function can lead to a number of premature ageing diseases, such as aplastic anaemia and pulmonary fibrosis. On the flip side, cancers can also activate ...

Telomeres are important to human health because dysregulation of either telomere protection or telomerase activity causes many human diseases. Notably, over 90% of human cancers activate telomerase ...

More information: Hong Seok Shim et al, TERT activation targets DNA methylation and multiple aging hallmarks, Cell (2024).

Scientists have long tried to unlock the secrets to helping people live longer at the cellular level, where aging occurs because of the gradual shortening of protective caps called telomeres at the ...