thus validating human telomerase reverse transcriptase as an important target for the development of anti-neoplastic therapies. To determine whether disruption of hTERT catalytic function would ...

We develop this knowledge by first understanding the core activities of key telomere factors, then testing these activities in a reconstituted telomerase assay and validating our knowledge directly in ...

Due to this phenomenon, scientists describe telomere length as a biological clock that indicates the lifespan of a cell and an organism. Telomerase is a ribonucleoprotein enzyme responsible for ...

Globally, scientists are working to unlock the secrets of extending human lifespan at the cellular level, where aging occurs ...

Their work has revealed how organisms rely on the enzyme to protect their genome from degradation, and laid the groundwork for later studies linking telomerase to cancer and aging-related ailments in ...

Researchers have developed HuT mice, a genetically engineered model with human-like telomeres, enabling scientists to study ...

Globally, scientists are working to unlock the secrets of extending human lifespan at the cellular level, where aging occurs gradually due to the shortening of telomeres–the protective caps at the ...

Their observations led them to hypothesize that TERT had other functions beyond synthesizing telomeres and that overall ...