Furthermore, telomere shortening due to the inability of the DNA-replication machinery ... these activities in a reconstituted telomerase assay and validating our knowledge directly in the organism.

She spoke to Adam Levy about her pioneering work on the structure and function of telomerase ... also kept her going through lockdown. DNA provides information that tells each cell what to ...

During DNA replication, the unwinding of strands leaves ... Because pol-a/primase always requires CMG function to create the ssDNA template, it could never surpass the DNA helicase (Figure 2b).

Our cells prevent this excessive shortening by adding telomeric DNA ... function at the molecular level, with implications for numerous diseases and disorders. "After the discovery of telomerase ...