Then, during the next round of DNA replication ... structure that depends on telomerase and other cellular factors for maintenance. Regulation of telomere function is an active area of current ...

Telomeric DNA does not encode ... in a reconstituted telomerase assay and validating our knowledge directly in the organism. The telomere provides a protective cap for the linear chomosome ends. In S.

Although the roles of the newly recognized polymerases are still being defined, one of their crucial functions is to allow synthesis past DNA damage that blocks replication-fork progression.

Our cells prevent this excessive shortening by adding telomeric DNA ... function at the molecular level, with implications for numerous diseases and disorders. "After the discovery of telomerase ...