Moreover, expression of this mutant telomerase eliminated tumorigenicity in vivo. These observations demonstrate that disruption of telomere maintenance limits cellular lifespan in human cancer ...

2 The potential drawback of the theoretical 'phenotypic lag' effect can be overcome by exploiting the selectivity of the telomerase gene for cancer cells using telomerase-directed gene therapy ...

Researchers at The University of Texas MD Anderson Cancer Center have identified a potential breakthrough in the fight ...

WSU researchers have created HuT mice with human-like short telomeres, allowing for groundbreaking studies on aging, cancer, ...

Led by WSU College of Pharmacy and Pharmaceutical Sciences Professor Jiyue Zhu, the research team has developed mice that have human-like short telomeres, enabling the study of cellular aging as it ...

The mouse model in the study is reportedly quite different as it allows scientists to observe the aging process in a whole ...

Globally, scientists are working to unlock the secrets of extending human lifespan at the cellular level, where aging occurs ...

Telomerase is a ribonucleoprotein enzyme responsible for maintaining telomere length ... 8 The observed association between shorter telomeres and increased risk of cancer, cardiovascular disease, and ...

Researchers have developed HuT mice, a genetically engineered model with human-like telomeres, enabling scientists to study ...

The laboratory is using or has plans to use many cutting-edge technological developments in cancer and aging genetics and translational research such as RRBS-seq and Single-cell epigenomics. Studies ...

MAIA Biotechnology Announces Positive Efficacy Updates for Phase 2 THIO-101 Trial in Advanced Non-Small Cell Lung Cancer ...

In the HuT mice, we modified this so they expressed much lower levels of telomerase enzyme in their tissues, essentially mimicking the human situation.” In contrast, cancer cells in humans ...