1). When paired with CG0070’s ability to lyse cancer cells, this immune activation ability gives the oncolytic virus a dual mechanism of action and unique potential to act as a powerful ...

Oncolytic viruses—viruses capable of preferential ... owing to its versatility and safety profile. The mechanism of action of VV is a combination of the direct destruction of cells via virus ...

oncolytic viruses may induce a powerful, long-lasting immune response that continues to shrink tumors for weeks or months after the virus is gone. This complementary tumor-killing mechanism is ...

Oncolytic virus therapy is not a new discovery ... Presently, protection mechanisms against viral infection, such as interferon‐beta signal pathway, can be impaired in the majority of cancer ...

Replication-selective oncolytic viruses are a rapidly expanding therapeutic platform for cancer ... In summary, this study provides insight into the antitumor mechanisms of oncolytic adenovirus, in ...

This comprehensive whitepaper analyzes the evolving landscape of oncolytic virus therapies (OVT), providing ... stimulate immune responses. This dual mechanism is creating new possibilities ...

Oncolytic viruses (OVs) are viruses that infect and kill cancer cells while sparing healthy tissue, making them a promising therapeutic option in cancer ...

Clinical Trials With Oncolytic NDV Several trials demonstrated ... strategies with greatest antitumor potential. Mechanisms of Newcastle disease virus-mediated antitumor effects.

Future Microbiol. 2012;7(3):347-367. Based on these findings, clinical trials utilizing immunization with ATV-NDV have been performed in patients with colorectal cancer, breast cancer, ovarian ...

It's not the first therapy in the oncolytic virus class to be approved around the world, as that accolade went to Amgen's Imlygic (talimogene laherparepvec), which was cleared by the FDA for the ...

Oncolytic virus therapies utilize genetically modified or naturally occurring viruses to selectively target tumor cells and stimulate immune responses. This dual mechanism is creating new ...

Pelareorep's mechanism of action as an oncolytic virus immunotherapy offers a novel approach to cancer treatment, potentially improving outcomes for patients with these types of cancer.