To determine the three-dimensional structure of small proteins such as transthyretin, researchers often turn to crystallography, in which proteins are forced into a large, repetitive crystal structure ...

AI accelerates drug development, cutting costs and boosting success rates. Discover how AI is reshaping the future of ...

Proteins are composed of one or more chains of amino acids, which are linked together by peptide bonds and folded into specific three-dimensional structures. Proteins have four levels of structure: ...

to build the three-dimensional atomic structure of large protein complexes, work recently published in Nature Communications.

Discover how AI tools like AlphaFold and RF Diffusion are revolutionizing protein folding design, medicine, and ...

Anfinsen, based on his studies of the ribonuclease enzyme, proposed that all the information needed to determine the tertiary structure of a protein ... Thus ensued the race to solve the ...

the accuracy of protein structure prediction remained low—a protein of even a few amino acids can take a wide range of structures. For many years, even the most successful computer programs could ...

Based on a protein’s three-dimensional surface structure, the algorithm designs molecules that bind specifically to the protein according to the lock- and-key principle, so they can interact ...

Every cell in your body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These ...

In diseases like Parkinson's and Alzheimer's, specific proteins misfold and clump together, forming toxic aggregates that damage brain ...

Iowa State researchers are exploring the depths of human cells, which could hold the key to new cancer treatments.  Biology ...