Ayatollah Ali Khamenei’s remarks upend months of signals from Tehran that it wanted to negotiate over its rapidly advancing nuclear program.

Iran's supreme leader says negotiations with America “are not intelligent, wise or honorable,” after U.S. President Donald Trump suggested he wants nuclear talks with Tehran despite reimposing his “ maximum pressure ” approach to Iran.

Both President Trump and Iranian officials have shown interest in negotiations. Ayatollah Ali Khamenei called the idea unwise, but stopped short of ordering his government not to engage.