The tripartite structure of NRs is defined by a central ... Nuclear receptor co-regulators modulate the transcriptional potential of estrogen receptor activated by estradiol, SERMs or growth ...

"Instead of simply shutting down the estrogen receptor," Yang said ... More information: Zhanwen Du et al, The sequence–structure–function relationship of intrinsic ERα disorder, Nature ...

BCs can be further classified into three subtypes, based on their molecular identifications: Estrogen Receptor alpha (ERα)-positive, Her2 (human epidermal growth factor receptor 2)-positive, and ...

Breast cancers at all stages are defined by the structure of their genomes, researchers find. Targeting these processes early is likely to offer unexpected therapeutic avenues.