ADCs are composed of three components: a monoclonal antibody targeting a tumor-associated or tumor-specific antigen; a potent cytotoxic agent; and a linker that covalently binds the antibody with ...
Antibody-drug conjugates (ADCs) are typically made of an antibody covalently attached to a cytotoxic drug via either a permanent or labile linker, thus making a highly heterogeneous product. Some of ...
Antibody-drug conjugates deliver chemotherapy by fusing a linker to a monoclonal antibody that attaches to a specific target expressed on cancer cells. Inside the cancer cell, a poisonous chemical ...
The theory behind antibody drug conjugates (ADCs) is simple yet elegant: by combining the specificity of a monoclonal antibody with the cytotoxicity of a potent small molecule drug, ADCs can ...