Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

The integrity of the blood-bone marrow barrier in calvarial BM blood vessels was lost after busulfan treatment in the young mice and remained altered even 6 weeks after HCT. In adult mice, the ...

The team's new device is a small plastic chip whose specially designed chambers are filled with human blood stem cells and the surrounding support cells with which they interact in a hydrogel to mimic ...

MSCs can differentiate into chondrocytes, bone marrow adipocytes (BMAs), and osteoblasts (bone-forming cells), while ... factor-1 (SDF-1), tumor necrosis factor alpha (TNF-α), interleukin-8 (IL-8), ...

In this review, we discuss the clinical potential of vascular progenitor and stem cells to restore long-lasting organ vascularization and function. Adult bone marrow is a rich reservoir of tissue ...

Borrowing nature's blueprint: How scientists replicated bone marrow Date: January 30, 2025 Source: University of Pennsylvania School of Engineering and Applied Science Summary: Researchers have ...