Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

Bone marrow is made of several main ingredients ... Reference: Georgescu A, Oved JH, Galarraga JH, et al. Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip.

For example, the skull is emerging as an important marrow niche in the pathogenesis of stroke. In both mice and humans, the bone marrow compartment of the skull is connected to the CNS by bone-encased ...

Stem cell therapy has come a long way since its early days. As an athlete who has undergone it twice, I know that the ...

Borrowing nature's blueprint: How scientists replicated bone marrow Date: January 30, 2025 Source: University of Pennsylvania School of Engineering and Applied Science Summary: Researchers have ...

A typical platelet count range can change with age. Platelet counts may fluctuate due to natural vascular aging, changes in bone marrow tissue, and altered blood plasma makeup. Platelets ...

Penn researchers have developed a platform that emulates human bone marrow’s native environment. This breakthrough addresses a critical need in medical science, as animal studies often fail to fully ...

Type 2 diabetes mellitus (T2DM) induces chronic inflammation, which can worsen the secondary injury following ischemic stroke. Yet, whether and how T2DM-induced inflammation affects the production of ...

The family has joined the National Marrow Donor Program, formerly known as Be the Match. A bone marrow transplant would be a complete cure for the little girl. “She would be able to go on and ...