骨髓是人体造血的“工厂”，而骨髓增生异常肿瘤（MDS）则是这座工厂的“生产线故障”——血细胞发育异常，导致贫血、感染甚至白血病风险升高。

For cell surface marker staining, splenocyte suspensions were incubated with the appropriate Abs, anti-CD3, anti-CD11b, anti-Ly6C, and anti-CD19 in PBS buffer (pH = 7.4) containing 0.2% BSA (BioSharp, ...

Myelin was removed using a 30% Percoll density gradient. Red blood cells were removed using ACK lysis buffer. The resulting cell pellet was stained with fluorophore-conjugated antibodies to CD45, CD3, ...

Background Treatment strategies for Crohn’s disease (CD) suppress diverse inflammatory pathways but many patients remain ...

8 Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA Correspondence to Dr Marina Pasca di Magliano, PhD, Department of Surgery and Department of Cell and Developmental ...

Xiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, China ...

肠道微生态平衡与免疫力密切相关，肠道菌群能够影响免疫反应和细胞因子分泌。肠道黏膜作为保护屏障，可防止有害物质进入，同时肠道也是重要的免疫球蛋白和抗体分泌器官。研究发现，肠道菌群失调与多种疾病的发生有关，在类风湿关节炎的病因研究中，微生物感染是近年来的热点。例如，大肠杆菌、结核分枝杆菌等感染与类风湿关节炎的发展相关，患者关节中可检测到肠道细菌降解的 DNA ...

1Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 2Department of Surgery, Keio ...

此外，此前研究发现缺失 NR2F6 可增强 T 细胞的抗肿瘤反应，尤其是在免疫检查点抑制期间。本研究进一步表明，在 NK 细胞中缺失 NR2F6 对于缺乏有效 T 细胞表位或下调 MHC-I 表达以逃避免疫监视的肿瘤可能具有重要意义，为联合治疗干预提供了潜在途径。然而，NKp46 表达增强在自身免疫性疾病如系统性红斑狼疮（SLE）中的作用仍有待进一步研究，需要深入探讨 NK 细胞上 NKp46 ...

Plates were coated overnight at 4°C with plate-bound anti-mouse CD3 antibody (2 μg/mL). Prior to plating ... Cells were then stained with zombie NIR (1:1000) and anti-CD16/32 (1:200) for 10 minutes ...