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The transcription factor NF-κB plays an important role in modulation of inflammatory pathways, which are associated with inflammatory diseases, neurodegeneration, apoptosis, immune responses, and ...

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ucl.ac.uk Results Dysregulated mitochondrial-associated gene expression correlated with increased ISG expression in JDM CD14+ monocytes. Altered mitochondrial-associated gene expression was paralleled ...

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The activated TAK1 further phosphorylates and activates the canonical IKK complex, ultimately leading to the activation factor NF-κB. The activation of TAK1 also leads to the activation of MAPKs, ...