We show that selective depletion of one subset of myeloid-derived suppressor cells (MDSC) in an autochthonous, genetically engineered mouse model (GEMM) of PDA unmasks the ability of the adaptive ...

1Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 2Department of Surgery, Keio ...

Ferroptosis is as potent anticancer target for the treatment of HCC and CRC liver metastasis in combination with immune checkpoint and MDSC blockade while primary CRC is resistant to this ...

Preclinical studies demonstrated that blockade of Bv8 decreases the recruitment of MDSC and angiogenesis (Shojaei et al ... Among TECs-targeting therapies, inhibitors of CXCR4 were scrutinized since ...

Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that neutrophils play an important role in the pathophysiology, particularly in those with severe disease courses.

aDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA bDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, ...

2 Institute of Molecular Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA 3 Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, ...