Gene expression is the generation of a functional gene product from the information encoded by a gene, through the processes of transcription and translation. Gene products are often proteins ...

The paper illustrates a valuable approach to generating TCR transgenic mice specific for known epitopes. Solid evidence validates the described pipeline for identification of TCRs from single-cell ...

Gene expression regulation in cancer and cellular functions Date: January 24, 2025 Source: The Korea Advanced Institute of Science and Technology (KAIST) Summary: A research team has identified ...

Objectives In the complex panorama of autoimmune diseases, the characterisation of pivotal contributing autoantibodies that are involved in disease progression remains challenging. This study aimed to ...

40 For in vitro experiments, KYNA and XANA were used at a concentration of 10–1000µM. HT-29 (10 000 cells per well, plated 72 hours before the experiment) or Jurkat cells (200 000 cells per well, ...

The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates ...

21 episode of the “Today” show. “Yeah, my dad went viral for these cutaway shots during yesterday’s broadcast. The internet’s obsessed with this little smile and goofy expression.” The next four years ...

1 Department of Pharmaceutics, Rutgers University, Piscataway, NJ, United States 2 Cancer Pharmacology Program, Cancer Institute of New Jersey, New Brunswick, NJ, United States This review article ...

This gene encodes the common leucocyte antigen, CD45, which is a haemopoietic cell-specific tyrosine phosphatase. CD45 is essential for the activation of T and B cells by mediating cell-to-cell ...

In recipient mice transplanted with old bone marrow, atherosclerosis regression was impaired, as evidenced by inefficient resolution of circulating inflammatory cell levels, reduced activation of ...