Notch Therapeutics is making “significant” layoffs to conserve its cash while the cell therapy biotech seeks out new partners or investors. The Canada-based company’s pipeline remains in ...

The Notch signaling pathway plays important roles in animal embryonic development and adult maintenance. We and others have shown that addition of O-linked glycans (carbohydrates) to Notch EGF repeats ...

Activation of the NOTCH1 receptor occurs when NOTCH ligands of the Jagged and Delta-like family bind to the extracellular subunit of NOTCH1. Ligand binding induces dissociation of the two subunits ...

A method for genetically barcoding Drosophila is developed and used to tag defined cell populations in vivo for single-cell transcriptomics experiments and to enable multiplexed behavioral analysis.

All organisms have various circadian, behavioral, and physiological 24-h periodic rhythms, which are controlled by the circadian clock. The circadian clock controls various behavioral and ...

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Authorities say deputies responded to Room Service on Two Notch Road about shots being fired and a fight in progress. Upon arrival, deputies started to search for a vehicle that was reported to ...