Briefly, cancer cells were seeded at 0.15x10 6 cells/ml in 100 µl volume in a 96-well tissue culture ... Granulocyte macrophage colony stimulating factor; EMT, Epithelial-to-mesenchymal transition; PT ...

TWIST1 can inhibit E-cadherin and promote the process of EMT. CADM1, generally highly expressed ... C- -Src is a non-receptor tyrosine kinase that is highly activated in colon cancer and induces the ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and ...

However, what types of heterogenous cancer cells in primary tumour and how they metastasise to the target organs remain largely undiscovered. Design We performed single-cell RNA sequencing and spatial ...

More than 67,000 Americans will be diagnosed with pancreatic cancer this year. Learn more about the disease and how PanCAN can help.

We integrated these transcriptional drug response profiles with a single-cell RNA-seq signature representing the transcriptional changes observed in triple-negative breast cancer cells compared to ...

“ID3+ T cells have the remarkable ability to resist burnout and maintain a powerful immune response over time, making them particularly effective in the face of chronic infections or cancer ...

Mitosis orchestrates eukaryotic cell division, maintaining genetic fidelity and playing a key role in development, tissue homeostasis, and cancer progression.