Colorectal cancer (CRC) is a major health problem, with an alarming increase of early-onset CRC (EO-CRC) cases among individuals under 50 years of age. This trend shows the urgent need for ...

Xilio Therapeutics Inc. has announced three wholly owned preclinical programs for masked T-cell engagers targeting prostate-specific membrane antigen (PSMA), claudin 18.2 (CLDN18.2) and ...

Also entered into collaboration and option agreement with AbbVie to develop novel tumor-activated immunotherapies, including ...

Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...

Although B cells can recognize and respond to antigen in various forms, the current view is that membrane-bound antigens are the predominant forms that initiate B-cell activation in vivo.

In this case, lysosome-associated membrane protein 2 isoform A (LAMP2a), together with heat shock cognate protein 70 (HSC70; also known as HSPA), can transport a cytoplasmic antigen to MHC class ...

The authors identify oleic acid as a particularly important metabolite, derived from seminal vesicle epithelium, that stimulates linear progressive motility in isolated cauda epidydimal sperm in vitro ...

The pleura (plural: pleurae) is a two-layered membrane that covers the lung. Between the layers is a small amount of lubricating fluid, known as pleural fluid, which helps cushion the lung and reduce ...

Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341000, China CAS Key Laboratory of Green Process and Engineering, State Key Laboratory of Multiphase Complex Systems, Beijing Key ...

Key Laboratory of New Membrane Materials, Ministry of Industry and Information Technology, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing ...

we will summarize the recent developments in the regulation of apico-basal membrane polarity by polarized membrane traffic and the formation of the intramembrane diffusion barrier in epithelial cells ...

In addition, the fate of antigens after inflammasome activation remains poorly understood. Conceivably, expulsion of pyroptotic epithelial cells may result in the loss of antigen, thereby hindering ...