Myosin II plays the most important role in cellular force generation. Myosin II molecules self-assemble into filaments with different structures depending on myosin II isoforms and other conditions ...

Visualization of filamentous actin (F-actin) in living cells is critical for the study of morphogenetic processes such as cell division, migration or polarization. We recently described in these ...

These data also suggest that Lifeact may be a useful tool to distinguish certain forms of f-actin in live cells. Note: Supplementary information is available on the Nature Methods website.

A new study published in Nature Communications shows that when a common cell structural protein called filamentous actin, or F-actin, builds up in the brain, it inhibits a key process that removes ...

In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and ...

Alushin's lab specializes in understanding the cytoskeleton—the network of protein filaments, including actin, that form a cell's infrastructure. Actin serves many functions: it provides cells ...