antibody-dependent cell-mediated phagocytosis, and extended serum half-life via interaction with neonatal Fc receptor. This review, therefore, focuses on the progress of Fc engineering in generating ...

This review summarizes recent progress in both natural and engineered structural modifications of IgG antibodies, including allotypic variation, glycosylation, Fc engineering, and Fc gamma receptor ...

IgM is the first antibody to be produced in a humoral immune response and plays an important role in the primary stages of immunity. Here we describe a mouse Fc receptor, designated Fcα/μR ...

The Vivacity-MG3 study is currently in its open-label extension phase, which is investigating the longer-term safety and ...

HOUSE, Pa. - Johnson & Johnson (NYSE: NYSE:JNJ) has released new data on nipocalimab, an investigational drug with potential to treat diseases driven by immunoglobulin G (IgG) antibodies. Published in ...

Antibodies and related products are the fastest growing class of therapeutic agents. By analysing the regulatory approvals of IgG-based biotherapeutic agents in the past 10 years, we can gain ...

lumc.nl Objective To determine whether anticitrullinated protein antibodies (ACPA) exhibit specific changes in Fc glycosylation prior to the onset of arthritis. Methods Serum samples of patients with ...

The table below is a review of notable updates that occurred in January 2025 for investigational products in development.

Antibodies that interfere with IL-6 function Tocilizumab is a monoclonal antibody directed against the IL-6 receptor that has established benefit in RA both with regards to clinical efficacy and ...

ANCA = antineutrophil cytoplasmic antibodies; CSF = cerebrospinal fluid; MELAS = mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes; NMDAR = N-methyl-D-aspartate receptor ...

Oxytocin receptor (Oxtr) signaling influences complex social behaviors in diverse species, including social monogamy in prairie voles. How Oxtr regulates specific components of social attachment ...