A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in ...

A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and ...

lead to a range of human neuromuscular and ophthalmologic diseases. Loss of function of the TLS polymerase Pol η leads to xeroderma pigmentosum-variant, a DNA repair and cancer predisposition ...

Huntington’s disease is a devastating neurodegenerative condition ... They demonstrated that lowering MSH3 did not disrupt DNA repair pathways, or trigger cancer signalling pathways. The team then ...

The past 30 years have seen a great advancement in our understanding of the various DNA repair pathways, both in prokaryotes and in higher organisms. An updated inventory of about 150 human DNA ...

Stanford scientists have identified 380 key genetic variants that significantly influence cancer development, filtering ...

Recently a human genetic study uncovered ... the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in Huntington's disease remained unknown.

These studies have consistently highlighted the role of DNA repair in influencing the age of onset and disease progression. Among the DNA repair genes identified ... but also because genetic studies ...