LPS receptor-deleted mice (i.e., CD14 mutants) are hypersensitive to insulin, and the occurrence of insulin resistance, obesity, and diabetes is delayed in response to high-fat feeding.

Furthermore, liver, but not whole-body, insulin resistance was detected in LPS-infused mice. CD14 mutant mice resisted most of the LPS and high-fat diet-induced features of metabolic diseases.

为解决 NACT 对乳腺癌患者外周单核细胞影响及预后贡献不明的问题，亚历山大大学研究人员开展相关研究。结果发现 NACT 影响 CD14+CD16 + 单核细胞和 sCD163 水平，且二者与临床反应有关。该研究为乳腺癌治疗提供新思路，值得一读。

Lipopolysaccharide (LPS) is the major component of the outer membrane of Gram-negative bacteria. This molecule can induce strong immune response and various biological effects. In mammals, TLR4 can ...

The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...

LPS also activates the Toll-like receptor (TLR)4-NF-κB signal transduction pathway through LPS-LBP-CD14 complexes, as well as promoting gene transcription and gene expression of many cytokines. Taken ...

We previously observed that lack of NADPH oxidases DUOX1 and DUOX2 resulted in reduced neutrophil influx in a VILI model of lung injury but had no influence on neutrophil influx after LPS exposure.

ucl.ac.uk Results Dysregulated mitochondrial-associated gene expression correlated with increased ISG expression in JDM CD14+ monocytes. Altered mitochondrial-associated gene expression was paralleled ...

were from Sigma and anti-human CD14 (clone RMO52) from Coulter Immunotech (Luton, UK). Synthesis of biotin-agarose. Biotin-agarose was prepared by sodium periodate oxidation of type IX-A ultra-low ...

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...

Anti-human antibodies included anti-NFIL3 (REA732) (Miltenyi Biotec), anti-CD14 (TuK4) (eBioscience); anti-CD3 (Miltenyi Biotec); anti-CD16 ... For cytokine production measurement, cells were ...