Unbiased expression profiling, and genetic and pharmacological gain-of-function and loss-of-function approaches were employed to identify molecular signalling in tumour-associated macrophages (TAMs) ...

Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose tissue dysfunction and contributing to obesity-induced inflammation and metabolic disorders. In this review, ...

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Macrophages are key effector cells that play a central ...

Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing ...

Dr. Won Jin Ho presented a talk as part of the Immunology Neighborhood Seminar on “Overcoming the tumor immune ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Macrophages are the primary cells responsible for nanoparticle processing and ...

肝脏巨噬细胞在调节肝细胞代谢和维持肝脏免疫耐受方面发挥核心作用。正常生理条件下，肝脏巨噬细胞倾向于 M2 表型，可通过分泌白细胞介素（IL）-4 和 IL-13 抑制炎症。然而，在 NAFLD 进展时，肝星状细胞激活、血液中脂多糖水平升高以及 FFA 激活炎症小体等变化，会刺激炎症发生，增加分泌促炎细胞因子的 M1 巨噬细胞比例。

zju.edu.cn Objective Macrophages are among the most abundant cells in the colon tumour microenvironment, and there is a close relationship among monocytes, macrophages and the gut microbiota.

1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...

This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the ...