The first generation of mAbs, unveiled in 1975 (ref. 1), were murine mAbs derived from mouse B-cell hybridomas (see “Monoclonal antibodies by design”). However, as murine mAbs moved into ...

The human EphA3 gene was discovered in a pre-B acute lymphoblastic leukemia (pre-B-ALL) using the EphA3-specific monoclonal ... IIIA4 antibody was engineered into both a murine-IgG2a backbone ...

[17] Their method followed a simple principle: fusion of spleen cells from a mouse immunized with an antigen of interest with nonsecretory murine ... clinical monoclonal antibody trials in MS ...

However, research has been hindered by a lack of effective markers and monoclonal antibodies to accurately ... stromal cells within optically cleared murine bone hemisections.

Bone marrow plays a crucial role in maintaining hematopoietic stem cells and bone homeostasis. However, research has been hindered by a lack of effective markers and monoclonal antibodies to ...

In a recent study, scientists have introduced an innovative imaging technique that provides an unparalleled view of the bone marrow’s intricate structure, focusing on leptin receptor-expressing (LepR+ ...