No writing assistance was utilized in the production of this manuscript. Monoclonal antibodies are novel therapeutic agents used with great success in the treatment of rheumatoid arthritis (RA).

Introduction: Humanization is typically adopted to reduce the immunogenicity of murine antibodies generated by hybridoma technology when used in humans. Methods: Two different strategies of antibody ...

[17] Their method followed a simple principle: fusion of spleen cells from a mouse immunized with an antigen of interest with nonsecretory murine ... clinical monoclonal antibody trials in MS ...

Patients using monoclonal antibody treatment vs standard of care had a significantly lower annualized exacerbation rate (RR, 0.82). Treating eosinophilic chronic obstructive pulmonary disease (COPD) ...

Methods: Immunoglobulin single chain variable domain fragments of a murine monoclonal antibody with specificity for rat CD4 were engineered with a 20 or 11 amino acid linker by assembly polymerase ...

We demonstrate here that administration of a CD154-specific monoclonal antibody (hu5C8 ... was done in a volume of 50 μl using 50 U Moloney murine leukemia virus reverse transcriptase (Stratagene ...

This different approach emphasizes the versatility of antibodies targeting TfR1. To maximize the human content of antibodies, development of fully human monoclonal antibodies was possible with the ...

Bone marrow plays a crucial role in maintaining hematopoietic stem cells and bone homeostasis. However, research has been hindered by a lack of effective markers and monoclonal antibodies to ...

However, research has been hindered by a lack of effective markers and monoclonal antibodies to accurately ... stromal cells within optically cleared murine bone hemisections.

Despite its vital role in "kick-starting" the immune response, IgD is arguably the least understood antibody, with little known about how it might participate in other parts of the immune system. A ...