These findings emphasize the importance of DNA repair pathways in DAC response and provide potential biomarkers. A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives ...

AAV载体是一种很有前途的基因传递载体，但其DNA包装能力有限。在这里，作者确定了细胞限制因子，其暂时抑制显著提高了分裂成双AAV载体的超大转基因的转导效率。

Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic cells using four Yamanaka transcription factors. Since their discovery, the stem cell (SC) field achieved ...