In 94% of cases, ALGS is caused by mutations in JAG1, which encodes one of the ligands for the Notch pathway. Patients with mutations in N-glycanase 1 (NGLY1) exhibit a host of developmental ...

Jagged1 是乳腺中表达最丰富的 Notch 配体，然而其在乳腺中的功能尚不清楚。已有研究表明，Jagged1 在乳腺癌中的作用复杂，在不同细胞系中的表现各异，如在管腔型乳腺癌 MCF-7 细胞中敲低 JAG1 会增加肿瘤球生长和癌症干细胞活性，而在三阴性乳腺癌 SUM149 细胞中 ...

Malignant cells with high delta-like ligand 4 (DLL4) expression interact with cancer-associated fibroblasts and endothelial cells via the DLL4-NOTCH signalling pathway to metastasise from primary CRC ...

2 Department of Rheumatology and Clinical Immunology, Semmelweis University, Budapest, Hungary 4 Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary 5 Heart and ...